Injury news in soccer is notoriously sketchy, so while the below information should be used as a guide, always check the confirmed lineups before every match.
Note: this column is updated throughout the week as injury news is released.
v. 
Gillette Stadium
Saturday, September 5 at 7:30 p.m. EDT
New England Revolution
Out:Darrius Barnes (knee), Jermaine Jones (international duty)
Orlando City SC
Suspended:Carlos Rivas
Out:Darwin Ceren (international duty), Conor Donovan (knee), Harrison Heath (kneecap), Kaka (international duty), Cyle Larin (international duty), Kevin Molino (knee)
Questionable:Tony Cascio (back), Seb Hines (undisclosed), Brek Shea (groin)
v. 
Stade Saputo
Saturday, September 5 at 8:00 p.m. EDT
Montreal Impact
Out:Kyle Bekker (international duty), Laurent Ciman (international duty), Maxime Crepeau (international duty), Eric Miller (international duty), Ambroise Oyongo (international duty), Cameron Porter (knee), Johan Venegas (international duty)
Doubtful:Kenny Cooper (knee), Adrian Lopez (knee)
Questionable:Hassoun Camara (knee), Didier Drogba (toe), Ignacio Piatti (calf)
Probable:Evan Bush (paternity)
Chicago Fire
Out:David Accam (international duty), Daneil Cyrus (international duty), Collin Fernandez (international duty), Adailton (groin), Joevin Jones (international duty), Matt Polster (international duty)
Questionable:Ty Harden (hamstring), Mike Magee (knee)
v. 
CenturyLink Field
Saturday, September 5 at 10:00 p.m. EDT
Seattle Sounders
Out:Victor Mansaray (international duty), Marco Pappa (international duty), Roman Torres (international duty)
Doubtful:Andres Correa (thigh)
Questionable:Andy Craven (knee), Clint Dempsey (hamstring), Leonardo Gonzalez (hamstring), Andreas Ivanschitz (quad), Damion Lowe (hip), Lamar Neagle (fatigue), Nelson Valdez (knock)
Toronto FC
Out:Jozy Altidore (international duty), Mark Bloom (quad), Sebastian Giovinco (thigh)
Questionable:Benoit Cheyrou (heel), Jackson (quad), Nick Hagglund (knee), Daniel Lovitz (undisclosed), Damien Perquis (quad), Clement Simonin (knee)
v. 
Avaya Stadium
Saturday, September 5 at 10:30 p.m. EDT
San Jose Earthquakes
Out:Cordell Cato (international duty), Innocent (knee), Anibal Godoy (international duty), Steven Lenhart (knee), Sanna Nyassi (international duty), Marc Pelosi (international duty), Jordan Stewart (Achilles)
Doubtful:Michael Fucito (hamstring)
Questionable:Abdul-Fatai Alashe (hamstring), Jean-Baptiste Pierazzi (foot)
Philadelphia Union
Suspension:Cristian Maidana
Out:Andre Blake (international duty)
Doubtful:Maurice Edu (groin), Zach Pfeffer (groin)
Questionable:Fred (quad), Jimmy McLaughlin (concussion), Brian Sylvestre (hand)
v. 
Mapfre Stadium
Saturday, September 6 at 7:00 p.m. EDT
Columbus Crew
Out:Harrison Afful (international duty), Sergio Campbell (international duty), Waylon Francis (international duty), Kei Kamara (international duty), Sagi Lev-Ari (knee), Cedrick Mabwati (international duty), Justin Meram (international duty), Ben Swanson (international duty), Will Trapp (international duty)
Questionable:Emanuel Pogatetz (knee), Gaston Sauro (match fitness), Kevan George (international duty)
FC Dallas
Out:Tesho Akindele (international duty), Fabian Castillo (international duty), Coy Craft (international duty), Blas Perez (international duty), Je-Vaughn Watson (international duty), Moises Hernandez (international duty)
Doubtful:Stephen Keel (foot)
Questionable:Mauro Diaz (quad), Dan Kennedy (knee)
