Indianapolis Colts vs San Francisco 49ers Odds, Week 16, 2025

#1 SS

Nick Cross: Logs seven tackles in loss

Dec 15th

Cross recorded seven tackles (four solo) in Sunday's loss to the Seahawks.

#1 WLB

Germaine Pratt: Double-digit tackles in Week 15

Dec 15th

Pratt recorded 10 tackles (five solo) in the Colts' loss to the Seahawks on Sunday.

#1 MLB

Zaire Franklin: Double-digit tackles in defeat

Dec 15th

Franklin recorded 10 tackles (seven solo) in the Colts' 18-16 loss to the Seahawks on Sunday.

#1 RDE

Laiatu Latu: Defensive star in loss

Dec 15th

Latu had three total tackles, including 1.0 sacks and two additional tackles for loss in Sunday's loss at Seattle.

#1 QB

Philip Rivers: Remaining starter for Week 16

Dec 15th

Colts head coach Shane Steichen said Rivers will draw another start during Monday Night Football against the 49ers in Week 16 on Dec. 22, James Boyd of The Athletic reports.

#4 QB

Anthony Richardson: Medically cleared, still on IR

Dec 15th

Richardson (orbital) has been cleared to resume football activities, but it remains uncertain whether he will return for Indianapolis' final three games of the regular season, Mike Chappell of Fox 59 News Indianapolis reports.

#2 RB

Ameer Abdullah: Leads team in receiving Sunday

Dec 14th

Abdullah rushed four times for 15 yards and caught all five of his targets for 32 yards in Sunday's 18-16 loss to the Seahawks.

#3 WR

Josh Downs: Catches TD from Rivers

Dec 14th

Downs caught three of five targets for 13 yards and a touchdown in Sunday's 18-16 loss to the Seahawks.

#2 WR

Alec Pierce: One snag in defeat

Dec 14th

Pierce caught his only target for 16 yards in Sunday's 18-16 loss to the Seahawks.

#1 TE

Tyler Warren: Little production on six targets

Dec 14th

Warren brought in three of six targets for 19 yards in Sunday's 18-16 loss to Seattle.

#1 WR

Michael Pittman: Quiet in Rivers' first start w/ IND

Dec 14th

Pittman had three receptions on five targets for 26 yards in Sunday's 18-16 loss to the Seahawks.

#1 K

Blake Grupe: Makes 60-yard field goal

Dec 14th

Grupe connected on all three field-goal attempts, including a 60-yarder, and his only extra-point try in Sunday's 18-16 loss to the Seahawks.

#1 RB

Jonathan Taylor: Grinds for over 100 yards in loss

Dec 14th

Taylor rushed 25 times for 87 yards while bringing in three of four targets for 14 receiving yards in Sunday's 18-16 loss to Seattle.

#1 LT

Bernhard Raimann: Questionable to return

Dec 14th

Raimann (elbow) is questionable to return to Sunday's matchup against Seattle.

#3 QB

Brett Rypien: Inactive in Week 15

Dec 14th

Rypien (coach's decision) is inactive as the Colts' emergency No. 3 quarterback for Sunday's game against the Seahawks.

#5 QB

Daniel Jones: Undergoes surgery on Achilles

Dec 13th

Jones underwent surgery Tuesday to repair a torn right Achilles that he suffered in Week 14 against the Jaguars, Adam Schefter of ESPN reports.

#2 LDE

Tyquan Lewis: Ready for Sunday

Dec 13th

Lewis (ankle) has been upgraded and carries no injury designation ahead of Sunday's matchup against the Seahawks.

#2 RT

Braden Smith: Shifts to IR

Dec 13th

Smith (concussion/neck) was placed on the injured reserve list Saturday.

#2 QB

Riley Leonard: Headed for backup role Week 15

Dec 13th

Leonard is expected to serve as the Colts' backup quarterback in Sunday's game against the Seahawks, Ian Rapoport of NFL Network reports.

#5 WR

Anthony Gould: Won't play Sunday

Dec 12th

Gould (foot) has been ruled out ahead of Sunday's matchup against the Seahawks.

#1 LCB

Sauce Gardner: Won't return for Week 15

Dec 12th

Gardner (calf) has been ruled out ahead of Sunday's matchup against the Seahawks.

#2 DT2

DeForest Buckner: Won't return Sunday

Dec 12th

Buckner (neck) has been ruled out ahead of Sunday's matchup against the Seahawks, JJ Stankevitz of the Colts' official site reports.

#3 LDE

JT Tuimoloau: Sidesteps injury report

Dec 11th

Tuimoloau (head) is not listed on Wednesday's injury report.

#3 RCB

Charvarius Ward: Hits IR with third concussion

Dec 10th

The Colts placed Ward (concussion) on injured reserve Wednesday.

#3 RB

Tyler Goodson: Plays one offensive snap

Dec 10th

Goodson failed to record a single carry or target in Sunday's 36-19 loss to the Jaguars.

#2 SCB

Chris Lammons: Moved to injured list

Dec 9th

The Colts placed Lammons (foot) on injured reserve Tuesday, JJ Stankevitz of the team's official site reports.

#3 WLB

Jaylon Carlies: Activated off IR

Dec 6th

The Colts activated Carlies (ankle) off injured reserve Saturday.

#1 SCB

Kenny Moore: Upgrades to full participation

Dec 4th

Moore (illness/ankle) was a full participant in Thursday's practice.

#1 FS

Camryn Bynum: Picks off Stroud in Week 13 loss

Dec 2nd

Bynum posted six tackles (four solo) and an interception during the Colts' 20-16 loss to the Texans on Sunday.